Microsatellite Instability in Primary and Metastatic Melanoma
نویسندگان
چکیده
منابع مشابه
Comparison of c-Kit expression between primary and metastatic melanoma of skin and mucosa
Background: Melanoma causes the greatest morbidity and mortality of all skin cancers. Mucosal melanoma is a rare but highly aggressive neoplasm. According to previous studies the prevalence of KIT mutations in acrallentiginous and mucosal melanomas is relatively low (less than 15–20%), but it can have profound therapeutic implications for localized high risk or metastatic diseases. Our goal w...
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Alterations in microsatellite sequences characterize hereditary nonpolyposis colorectal cancer. This microsatellite instability is due in some kindreds to a germline mutation of the mismatch repair gene hMSH2 on chromosome 2p. Although microsatellite alterations have been reported in other hereditary nonpolyposis colorectal cancer-associated tumors including endometrial and gastric cancers, suc...
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متن کاملcomparison of c-kit expression between primary and metastatic melanoma of skin and mucosa
background: melanoma causes the greatest morbidity and mortality of all skin cancers. mucosal melanoma is a rare but highly aggressive neoplasm. according to previous studies the prevalence of kit mutations in acrallentiginous and mucosal melanomas is relatively low (less than 15–20%), but it can have profound therapeutic implications for localized high risk or metastatic diseases. our goal was...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 1997
ISSN: 0022-202X
DOI: 10.1111/1523-1747.ep12276783